Build Strength. Preserve Memory. Delay Alzheimer’s.
Our evidence-based program leverages powerful lifestyle strategies to support brain health and longevity.
The Science Behind the Strategy
Alzheimer’s is a progressive brain disorder that starts silently in midlife and is deeply linked to physical health. E4 Strength delivers personalized, science-based strategies rooted in exercise, sleep, nutrition, and connection to protect cognitive health, boost resilience, and improve long-term aging outcomes.
The Four Pillars of E4 Strength
At E4 Strength, these four pillars form the structure of our integrated approach to aging well. When personalized to your needs, they help you move better, think sharper, and enjoy better quality of life.
How It Works
Discover our science-backed method
Why I Built E4 Strength
I’m Dr. Alfonso Alfini — a former NIH program director, Johns Hopkins faculty member, high school teacher and coach. My passion lies in translating science into practical strategies that help people live stronger, sharper, and more independent lives.
For the past two decades, I’ve studied how movement, sleep, and nutrition shape brain health, aging, and performance. I created E4 Strength to apply that science beyond the lab, where it matters most.
This program is for people who want to take an active role in aging well. It blends emerging research with proven methods to build strength and support cognitive resilience.
Credentials & Experience
- Program Director, National Center on Sleep Disorders Research (NIH)
- Faculty, Neurology & Aging, Johns Hopkins School of Medicine
- PhD, Exercise Physiology & Cognitive Neuroscience
- Master’s, Strength & Conditioning, Certified CSCS
- College Athlete, Coach & High School Teacher
What You’ll Get with E4 Strength
E4 Strength is a comprehensive health training system that translates neuroscience and exercise physiology into real-world application. Every element, from workouts to recovery tools, is designed to help you build strength and sharpen your mind.
Early-bird perks & exclusive tips
How E4 Strength Works
E4 Strength is a research-driven system designed for real life. It helps you build strength, move with confidence, and protect your mind.
We begin by clarifying your goals and evaluating key lifestyle factors—movement, sleep, nutrition, and social ties. This step establishes a personalized framework for progress grounded in evidence, not guesswork.
Engage in structured training and behavior change strategies that target strength, recovery, and cognitive health. Each action builds on the last—supporting consistent progress through science-backed habits and measurable wins.
As new routines take hold, we shift focus to long-term integration. You’ll build the ability to maintain results, adapt with confidence, and carry forward a foundation for aging well.
Train Smarter. Age Stronger. Start Here.
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